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VOLUME 10 , ISSUE 1 ( January-June, 2021 ) > List of Articles


SARS-CoV-2 Infection and ACE-2 Expression in Children: An Overview

Jayalakshmi Pandranki, Jai Kiran Killada, Maddula Madhavi Krishna

Keywords : Angiotensin-converting enzyme 2, Clinical manifestations, Coronavirus disease-2019 in children, SARS-CoV-2

Citation Information : Pandranki J, Killada JK, Krishna MM. SARS-CoV-2 Infection and ACE-2 Expression in Children: An Overview. Int J Experiment Dent Sci 2021; 10 (1):19-24.

DOI: 10.5005/jp-journals-10029-1218

License: CC BY-NC 4.0

Published Online: 11-08-2021

Copyright Statement:  Copyright © 2021; The Author(s).


SARS-CoV-2 has marked a new era in the medical field with a wide array of signs and symptoms. The clinical manifestations may vary from simple sore throat to severe multiple organ failure causing death in adults. The severity of the disease was relatively mild in children compared to adults but the preliminary evidence reveals high proportions of asymptomatic infection which contributes to a viral transmission. It still remains ambiguous why children are less severely affected than adults. This literature provides a comprehensive review of epidemiology, vulnerability, pathophysiology, organ-specific systemic manifestations of coronavirus disease-2019 (COVID-19), its clinical course similarities and differences between child and adult with a special focus on the reasons behind the reduced disease severity in children.

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