International Journal of Experimental Dental Science

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VOLUME 10 , ISSUE 2 ( July-December, 2021 ) > List of Articles


The Efficacy of Photobiomodulation in Wound healing following Gingivectomy: A systematic Review of clinical Studies

Sandeep Talluri, Maryam Altuhafy, Junad Khan

Keywords : Gingivectomy, Lasers, Photobiomodulation, Wound healing

Citation Information : Talluri S, Altuhafy M, Khan J. The Efficacy of Photobiomodulation in Wound healing following Gingivectomy: A systematic Review of clinical Studies. Int J Experiment Dent Sci 2021; 10 (2):63-70.

DOI: 10.5005/jp-journals-10029-1235

License: CC BY-NC 4.0

Published Online: 17-02-2023

Copyright Statement:  Copyright © 2021; The Author(s).


Background: There is a controversy regarding the efficacy of photobiomodulation (PBM) in soft tissue healing following gingival procedures. The aim of the current study was to systematically review the efficacy of PBM in wound healing following a gingivectomy. The addressed focus question was, “Is PBM effective in wound healing following gingivectomy?” Indexed databases [Public/Publisher MEDLINE (PubMed), Excerpta Medica dataBASE (EMBASE), Web of Science, and Cochrane] were searched up to December 2020. The risk of bias (RoB) was assessed using Joanna Briggs critical appraisal tool for randomized control trials (RCTs) and case-control studies. Methods: A total of eight studies, six RCTs and two case-control studies, were included in the present review. Seven studies with varying results indicated that PBM application following gingivectomy could enhance wound healing as early as 7 days and help in the reduction of postoperative pain. Wound healing was assessed using either Landry index (two studies), contour, and color of gingiva postsurgically (two studies), or visual analog scale (VAS) scores (three studies) and plaque disclosing solution to measure keratinization in one study. Conclusion: The efficacy of PBM in wound healing following gingivectomy is debatable as the heterogeneity associated with the included studies was high, but overall, the review supports PBM as an adjunctive tool for the promotion of wound healing following gingivectomy. The overall RoB was low in the included studies, further power-adjusted and well-designed RCTs with long-term follow-up are needed.

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  1. Moffitt M, Cohen R. Non-drug induced gingival enlargement. Gen Dent 2013;61(5):e10–e13.
  2. Ibrahim M, Abouzaid M, Mehrez M, et al. Genetic disorders associated with gingival enlargement. Gingival Disease 2011;9:189–209. DOI: 10.5772/23389
  3. Bharti V, Bansal C. Drug-induced gingival overgrowth: the nemesis of gingiva unraveled. J Indian Soc Periodontol 2013;17(2):182–187. DOI: 10.4103/0972-124X.113066
  4. Brunet L, Miranda J, Farre M, et al. Gingival enlargement induced by drugs. Drug Saf 1996;15(3):219–231. DOI: 10.2165/00002018-199615030-00007
  5. Amorim J, Sousa G, Silveira L, et al. Clinical study of the gingiva healing after gingivectomy and low-level laser therapy. Photomed Laser Surg 2006;24(5):588–594. DOI: 10.1089/pho.2006.24.588
  6. Kohale B, Agrawal A, Raut P. Effect of low-level laser therapy on wound healing and patients’ response after scalpel gingivectomy: a randomized clinical split-mouth study. J Indian Soc Periodontol 2018;22(5):419–426. DOI: 10.4103/jisp.jisp_239_18
  7. Akram H, Ali O, Omran N, et al. Diode laser versus scalpel gingivectomy. Biomed Pharmacol J 2017;10(4):1799–1704. DOI: 10.13005/bpj/1295
  8. Degim Z, Celebi N, Sayan H, et al. An investigation on skin wound healing in mice with a taurine-chitosan gel formulation. Amino Acids 2002;22(2):187–198. DOI: 10.1007/s007260200007
  9. Cotler H, Chow R, Hamblin M, et al. The use of low level laser therapy (LLLT) for musculoskeletal pain. MOJ Orthop Rheumatol 2015;2(5):00068. DOI: 10.15406/mojor.2015.02.00068
  10. Aoki A, Mizutani K, Schwartz F, et al. Periodontal and peri-implant wound healing following laser therapy. Periodontol 2000 2015;68(1):217–269. DOI: 10.1111/prd.12080
  11. Silveira P, Silva L, Fraga D, et al. Evaluation of mitochondrial respiratory chain activity in muscle healing by low-level laser therapy. J Photochem Photobiol B 2009;95(2):89–92. DOI: 10.1016/j.jphotobiol.2009.01.004
  12. Huang Y, Chen A, Carroll J, et al. Biphasic dose response in low level light therapy. Dose Response 2009;7(4):358–383. DOI: 10.2203/dose-response.09-027.Hamblin
  13. Alexandratou E, Handris D, Kletsas D, et al. Human fibroblast alterations induced by low power laser irradiation at the single cell level using confocal microscopy. Photochem Photobiol Sci 2002;1(8):547–552. DOI: 10.1039/b110213n
  14. Conlan MJ, Rapley JW, Cobb CM. Biostimulation of wound healing by low-energy laser irradiation. A review. J Clin Periodontol 1996;23(5):492–496. DOI: 10.1111/j.1600-051x.1996.tb00580.x
  15. Shamseer L, Moher D, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 2015;350:g7647. DOI: 10.1136/bmj.g7647
  16. Hammadi A. Clinical assessment of low level laser (GaAlAs) on gingivectomy wound healing. Med J Babylon 2013;10(2):349–353.
  17. Lingamaneni S, Mandadi L, Pathakota K. Assessment of healing following low-level laser irradiation after gingivectomy operations using a novel soft tissue healing index: a randomized, double-blind, split-mouth clinical pilot study. J Indian Soc Periodontol 2019;23(1):53–57. DOI: 10.4103/jisp.jisp_226_18
  18. Madi M, Mahmoud M. The evaluation of healing effect of low-level laser treatment following gingivectomy. Beni-Suef Univ J Basic Appl Sci 2020;9:25. DOI: 10.1186/s43088-020-00053-z
  19. Ozcelik O, Haytac M, Kunin A, et al. Improved wound healing by low-level laser irradiation after gingivectomy operations: a controlled clinical pilot study. J Clin Periodontol 2008;35(3):250–254. DOI: 10.1111/j.1600-051X.2007.01194.x
  20. Reddy S, Koduganti R, Panthula V, et al. Efficacy of low-level laser therapy, hyaluronic acid gel, and herbal gel as adjunctive tools in gingivectomy wound healing: a randomized comparative clinical and histological study. Cureus 2019;11(12):e6438. DOI: 10.7759/cureus.6438
  21. Uslu M, Akgül S. Evaluation of the effects of photobiomodulation therapy and ozone applications after gingivectomy and gingivoplasty on postoperative pain and patients’ oral health-related quality of life. Lasers Med Sci 2020;35(7):1637–1647. DOI: 10.1007/s10103-020-03037-8
  22. Moola S, Munn Z, Sears K, et al. Conducting systematic reviews of association (etiology): the Joanna Briggs Institute's approach. Int J Evid Based Healthc 2015;13(3):163–169. DOI: 10.1097/XEB.0000000000000064
  23. Peck S, Peck L, Kataja M. The gingival smile line. Angle Orthod 1992;62(2):91–100. DOI: 10.1043/0003-3219(1992)062<0091:TGSL>2.0.CO;2
  24. Gordon S, Surrey K. Red and far-red action on oxidative phosphorylation. Radiat Res 1960;12(4):325–339. DOI: 10.2307/3571041
  25. Lubart R, Eichler M, Lavi R, et al. A low-energy laser irradiation promotes cellular redox activity. Photomed Laser Surg 2005;23(1):3–9. DOI: 10.1089/pho.2005.23.3
  26. Damante C, Greghi S, Ana A, et al. Histomorphometric study of the healing of human oral mucosa after gingivoplasty and low-level laser therapy. Lasers Surg Med 2004;35(5):377–384. DOI: 10.1002/lsm.20111
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