International Journal of Experimental Dental Science

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VOLUME 4 , ISSUE 1 ( January-June, 2015 ) > List of Articles

RESEARCH ARTICLE

Associations between Periodontal Disease Parameters and Coronary Heart Disease in Greek Adults: A Cross-sectional Study

Nikolaos Andreas Chrysanthakopoulos, Aggelos Antonios Oikonomou, Panagiotis Andreas Chrysanthakopoulos

Citation Information : Chrysanthakopoulos NA, Oikonomou AA, Chrysanthakopoulos PA. Associations between Periodontal Disease Parameters and Coronary Heart Disease in Greek Adults: A Cross-sectional Study. Int J Experiment Dent Sci 2015; 4 (1):4-10.

DOI: 10.5005/jp-journals-10029-1087

Published Online: 01-06-2017

Copyright Statement:  Copyright © 2015; The Author(s).


Abstract

Aim

Several forms of periodontal disease have been associated with the development of coronary heart disease. The current retrospective study was conducted to investigate the possible relationship between periodontal disease parameters and defined coronary heart disease (CHD) in Greek adult patients.

Materials and methods

The study sample consisted of 880 individuals, 400 males and 480 females, aged 40 to 78 years. Data were collected by means of an interviewer administered questionnaire and an oral clinical examination. Statistical analysis of the questionnaire items was performed by using multiple regression analysis model in order to assess possible associations between coronary heart disease as dependent variable and epidemiological variables, biomarkers and periodontal disease parameters as independent variables.

Results

The occurrence of hypertension (OR = 0.01, 95% CI = 0.09-1.33), high level of triglycerides (OR = 0.08, 95% CI = 0.06-2.27) and total cholesterol (OR = 0.08, 95% CI = 0.07- 1.27), low level of high-density lipoprotein (OR = 0.12, 95% CI = 0.09-3.70) and smoking (OR = 1.83, 95% CI = 0.38-8.88) were significantly associated with the presence of coronary heart disease, whereas the periodontal parameters examined were not associated with the occurrence of it.

Conclusion

No associations were observed between periodontal disease parameters and defined coronary heart disease. However, the recorded associations strengthen the role of hypertension, lipids and smoking as causative risk factors of coronary heart disease.

How to cite this article

Chrysanthakopoulos NA, Oikonomou AA, Chrysanthakopoulos PA, Saini R. Associations between Periodontal Disease Parameters and Coronary Heart Disease in Greek Adults: A Cross-sectional Study. Int J Experiment Dent Sci 2015;4(1):4-10.


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  1. The pathogenesis of atherosclerosis. Clin Chim Acta 1996;246(1-2):21-38.
  2. Global cardiovascular health promotion and disease prevention: 2011 and beyond. Circulation 2012;125(21):2667-2676.
  3. Can the relation between tooth loss and chronic disease be explained by socioeconomic status? A 24-year follow-up from the population study of women in Gothenburg, Sweden. Eur J Epidemiol 2005;20(3):229-236.
  4. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. New Engl J Med 2000; 342(12):836-843.
  5. Current view of risk factors for periodontal diseases. J Periodontol 1996;67(suppl 10):1041-1049.
  6. Examination of the relation between periodontal health status and cardiovascular risk factors: serum total and high-density lipoprotein cholesterol, C-reactive protein and plasma fibrinogen. Am J Epidemiol 2000;151(3):273-282.
  7. Potential correlation between periodontitis and coronary heart disease an overview. Gen Dent 2012;60(1): 20-24.
  8. Periodontal diseases and cardiovascular events: meta-analysis of observational studies. Int Dent J 2009;59(4):197-209.
  9. Effect of periodontal treatment on lipoproteins levels in plasma in patients with periodontitis. South Med J 2011;104(8):547-552.
  10. Poor oral health in patients with coronary heart disease: a case-control study of Indian adults. NZ Med J 2011; 124(1347):53-62.
  11. Do genetic factors explain the association between poor oral health and cardiovascular disease? A prospective study among Swedish twins. Am J Epidemiol 2009;170(5):615-621.
  12. Plasma lipid and blood glucose levels in patients with destructive periodontal disease. J Clin Periodontol 2000;27(8):537-541.
  13. Clinically classified periodontitis and its association in patients with pre-existing coronary heart disease. J Oral Dis 2013; DOI: org/10.1155/2013/243736.
  14. Relationship of cigarette smoking to attachment level profiles. J Clin Periodontol 2001;28(4): 283-295.
  15. Confounding and effect modification; possible explanation for variation in the results on the association between oral and systemic diseases. J Clin Periodontol 2006;33(2):104-108.
  16. Systemic inflammation in cardiovascular and periodontal disease: comparative study. Clin Diagn Lab Immunol 2002;9(2):425-432.
  17. Candidate genes as potential links between periodontal and cardiovascular diseases. Ann Periodontol 2001;6(1):48-57.
  18. Periodontal disease and heart disease: are they related? Gen Dent 2008;56(7):733-737, quiz 738-9,768.
  19. Number of teeth as a predictor of cardiovascular mortality in a cohort of 7,674 subjects followed for 12 years. J Periodontol 2010;81(6):870-876.
  20. The relationship of periodontal disease to cardiovascular diseases—review of literature. J Pak Med Assoc 2006;56(4):177-181.
  21. Clinical indicators of periodontal disease in patients with coronary heart disease: a 10 years longitudinal study. Med Oral Patol Oral Cir Bucal 2012;17(4):e569-e574.
  22. AHA/ACC scientific statement: AHA/ACC guidelines for preventing heart attack and death in patients with atherosclerotic cardiovascular disease: 2001 update: a statement for health care professionals from the American Heart Association and the American College of Cardiology. Circulation 2001;104:1577-1579.
  23. The gingival index, the plaque index, and the retention index systems. J Periodontol 1967;38(6):610-616.
  24. Comparison of results following three modalities of periodontal therapy related to tooth type and initial pocket depth. J Clin Periodontol 1980;7(1):32-47.
  25. The periodontal disease classification system of the American Academy of Periodontology: an update. J Can Dent Assoc 2000;66:594-597.
  26. Endothelium, coronary vasodilatation and organic nitrates. Am Heart J 1995;129(2):382-391.
  27. Hyperlipidemia in patients with periodontitis. J Contemp Dent Pract 2005;6(3):78-85.
  28. Gingivitis, dental caries and tooth loss: risk factors for cardiovascular diseases or indicators of elevated health risks. J Clin Periodontol 2006;33(2):92-101.
  29. The association between tooth loss and the self-reported intake of selected cardiovascular disease-related nutrients and foods among US women. Comm Dent Oral Epidemiol 2005;33(3):167-173.
  30. Pathophysiology, diagnosis and management of dyslipidemia. Curr Probl Cardiol 2006;31(7): 445-486.
  31. Coronary artery disease: the role of lipids, hypertension and smoking. Basic Res Cardiol 2000;95(Suppl 1):152-158.
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