International Journal of Experimental Dental Science

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VOLUME 4 , ISSUE 1 ( January-June, 2015 ) > List of Articles

RESEARCH ARTICLE

Evaluation of Effects of Different Immunosuppressant Agents on Gingival Overgrowth

Nilsun Bagis, Ahu Bekit, Nejat Arpak

Citation Information : Bagis N, Bekit A, Arpak N. Evaluation of Effects of Different Immunosuppressant Agents on Gingival Overgrowth. Int J Experiment Dent Sci 2015; 4 (1):17-22.

DOI: 10.5005/jp-journals-10029-1089

Published Online: 01-06-2017

Copyright Statement:  Copyright © 2015; The Author(s).


Abstract

Background

The purpose of this study is to evaluate the effects of different immunosuppressant agents on gingival overgrowth.

Materials and methods

About 60 patients medicated with cyclosporin A (CsA) and 40 patients with tacrolimus (TcR) were recruited in the study. Periodontal examination (PI, GI, PBI, PPD, GO) was carried out only for maxillary and mandibular anterior teeth. Pharmacologic variables, such as daily dosage of immunosuppressant agents, TcR/CsA whole blood level were recorded.

Results

In the group medicated with CsA, 10 patients had clinically significant GO, while none of the patients medicated with Tac had clinically significant GO. Significant differences were observed for periodontal parameters (PI, GI, PBI, PPD), post-transplant period, percentage of GO. In CsA group, significant difference was detected for periodontal parameters, percentage of GO and daily glucocorticoid dosage between responders and nonresponders.

Conclusion

The results from our study show that GO does not occur in patients medicated with TcR, although TcR shares same mechanism with CsA.

How to cite this article

Bekit A, Bagis N, Arpak N. Evaluation of Effects of Different Immunosuppressant Agents on Gingival Overgrowth. Int J Experiment Dent Sci 2015;4(1):17-22.

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  1. Cyclosporin-A in clinical organ grafting. Transplant Proc 1981 Mar;13(1 Pt 1):349-358.
  2. Gingival hyperplasia induced by cyclosporin-A. Br Dent 1984;157(9):305-309.
  3. Kidney transplantation under FK 506. JAMA 1990;264(1):63-67.
  4. Initial observation that cyclosporin-A induces gingival enlargement in man. J Clin Periodontol 1983;10(3):237-246.
  5. Gingival enlargement among renal transplant recipients in the era of new-generation immunosuppressants. J Periodontol 2008;79(3):453-460.
  6. Tacrolimus is not associated with gingival overgrowth in renal transplant patients. J Clin Periodontol 2001;28(9):848-852.
  7. Prevalence of gingival overgrowth in transplant patients immunosuppressed with tacrolimus. J Clin Periodontol 2004;31(2):126-131.
  8. A study of the effects of the drug FK 506 on gingival tissues. Transplant Proc 1991;23(6):3193-3194.
  9. Incidence of tacrolimus-induced gingival overgrowth in the absence of calcium channel blockers: A short-term study. J Clin Periodontol 2007;34(7):545-550.
  10. The prevalence and severity of cyclosporin and nifedipine-induced gingival overgrowth. J Clin Periodontol 1993;20(1):37-40.
  11. Factors related to the incidence and severity of cyclosporin-induced gingival overgrowth in transplant patients. A longitudinal study. J Periodontol 1994;65(7):671-675.
  12. The distribution of gingival overgrowth in organ transplant patients. J Clin Periodontol 1996;23(4):367-371.
  13. Prevalence, severity, and risk variables associated with gingival overgrowth in renal transplant subjects treated under tacrolimus or cyclosporine regimens. Journal of Periodontology 2006;77(6):969-975.
  14. Gingival overgrowth in renal transplant subjects medicated with tacrolimus in the absence of calcium channel blockers. Transplantation 2008;85(2): 232-236.
  15. Motivation and education (in German). SSO Schweiz Monatsschr Zahnheilkd 1975;85(9): 905-919.
  16. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121-135.
  17. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-551.
  18. The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients. J Clin Periodontol 1985;12(6):413-419.
  19. Relationship of putative periodontopathogenic bacteria and drug-induced gingival overgrowth. Zhonghua Kou Qiang Yi Xue Za Zhi 2008a;43(6): 347-351.
  20. Gingival overgrowth in renal transplant recipients: a study concerning prevalence, severity, periodontal, and predisposing factors. Transplantation Proceedings 2008;40(5):1425-1428.
  21. Drugassociated gingival enlargement. Journal of Periodontology 2004;75(10):1424-1431.
  22. Gingival enlargement among renal transplant recipients in the era of new-generation immunossupressants. Journal of Periodontology 2008;79(3):453-460.
  23. Oral health in renal transplant recipients administered cyclosporin A or tacrolimus. Oral Diseases 2006;12(3):309-314.
  24. Gingival overgrowth in subjects under immunosuppressive regimens based on cyclosporine, tacrolimus, or sirolimus. J Clin Periodontol 2010;37(10):894-902.
  25. Gingival overgrowth among patients medicated with cyclosporin A and tacrolimus undergoing renal transplantation: a prospective study. J Periodontol 2011 Feb;82(2):251-258.
  26. Drugs and the periodontium. J Clin Periodontol 1988;15(1):1-16.
  27. Drug induced gingival overgrowth. Oral Surg Oral Med Oral Pathol 1993; 76(4):543-548.
  28. The periodontal problems and management of the renal transplant patient. Review. Ren Fail 1994;16(6):731-745.
  29. Severe gingival overgrowth associated with cyclosporine therapy. J Periodontol 1986;57(5): 294-299.
  30. Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. Oral Surg Oral Med Oral Pathol 1987;64(3):293-297.
  31. Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. Periodontol 1992;63(6): 548-553.
  32. Risk factors for gingival overgrowth in patients medicated with ciclosporin in the absence of calcium channel blockers. J Clin Periodontol 2005; 32(3):273-279.
  33. The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients: A longitudinal study. J Clin Periodontol 1987;14(10):610-613.
  34. Morel A, Smith D, Koffman CG, Ogg CS, Rigden SP, Ashley FP. Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy. J Clin Periodontol 1998;25(6): 457-464.
  35. The pathogenesis of drug-induced gingival overgrowth. J Clin Periodontol 1996; 23(3 Pt 1):165-175.
  36. The role of drugs in the pathogenesis of gingival overgrowth. A collective review of current concepts. Review. Periodontol 2000 Oct, 1999;21:176-196.
  37. Iatrogenic gingival overgrowth in cardiac transplantation. Journal of Periodontology 1995;66(8):742-746.
  38. Gingival hyperplasia in renal allograft recipients receiving cyclosporin-A and calcium antagonists. J Clin Periodontol 1993;20(4):286-293.
  39. Prevalance of gingival overgrowth induced by calcium channel blockers, a community-based study. J Periodontol 1999;70(1):63-67.
  40. Clinical and pharmacologic correlations in cyclosporine induced gingival hyperplasia. Oral Surg Oral Med Oral Pathol 1986;62(4):417-421.
  41. Cyclosporine-A induced gingival overgrowth in renal transplant patients. J Periodontol 2003;74(1):51-56.
  42. Cyclosporin and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens. J Oral Pathol Med 1996;25(3): 128-134.
  43. Ozone therapy in dentistry: a strategic review. J Nat Sc Biol Med 2011;2(2):151-153.
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