International Journal of Experimental Dental Science

Register      Login

VOLUME 7 , ISSUE 1 ( January-June, 2018 ) > List of Articles


Effect of Antibiotic Prophylaxis on Serum C-reactive Protein Level Immediately following Periodontal Treatment: An Experimental Clinical Study

Nilsun Bagis, Basak Boduroglu, Cem A Gurgan, Hamit S Bostanci

Keywords : Antibiotic prophylaxis, C-reactive protein, Periodontal treatment

Citation Information : Bagis N, Boduroglu B, Gurgan CA, Bostanci HS. Effect of Antibiotic Prophylaxis on Serum C-reactive Protein Level Immediately following Periodontal Treatment: An Experimental Clinical Study. Int J Experiment Dent Sci 2018; 7 (1):23-29.

DOI: 10.5005/jp-journals-10029-1170

License: CC BY-SA 3.0

Published Online: 01-03-2010

Copyright Statement:  Copyright © 2018; The Author(s).


Introduction: The immediate rise in serum C-reactive protein (CRP) levels associated with the delivery of the subgingival instrumentation and the associated bacteremia and tissue damage was shown shortly after periodontal treatment was delivered. However, the additive effect of the protection against bacteremia on immediate alterations in CRP levels has not been evaluated. The aim of this study was to determine the immediate effect of single session of nonsurgical periodontal treatment with or without antibiotic prophylaxis on serum levels of CRP. Materials and methods: Forty systemically healthy subjects with chronic periodontitis were randomly assigned to two groups. Clinical periodontal parameters and smoking status were recorded. Serum CRP levels were determined using nephelometric method at baseline and 1, 3, and 7 days after treatment. Results: Except for the difference between baseline and day 7, there were significant differences (p < 0.001) in CRP levels between the evaluation days in both groups. However, the differences between the groups for the alterations were not significant. Conclusion: In agreement with previous observations, periodontitis and traumatic effect of periodontal treatment seem to contribute to systemic inflammation detected by the presence of immediate rise in the CRP level. Additional administration of prophylactic antibiotic did not alter this immediate systemic response.

PDF Share
  1. Ioannidou E, Malekzadeh T, Dongari-Bagtzoglou A. Effect of periodontal treatment on serum C-reactive protein levels: a systematic review and meta-analysis. J Periodontol 2006 Oct;77(10):1635-1642.
  2. Mattila K, Vesanen M, Valtonen V, Nieminen M, Palosuo T, Rasi V. Asikainen S. Effect of treating periodontitis on C-reactive protein levels: a pilot study. BMCl Infect Dis 2002 Dec;2:30-32.
  3. Ide M, McPartlin D, Coward PY, Crook M, Lumb P Wilson RF. Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J Clin Periodontol 2003 Apr;30(4):334-340.
  4. D'Aiuto F, Nibali L, Mohamed-Ali V, Vallance P Tonetti MS. Periodontal therapy: a novel non-drug-induced experimental model to study human inflammation. J Periodont Res 2004 Oct;39(5):294-299.
  5. D'Aiuto F, Parkar M, Andreaou G, Suvan J, Brett PM, Ready D Tonetti MS. Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dent Res 2004 Feb;83(2):156-160.
  6. D'Aiuto F, Nibali L, Parkar M, Suvan J Tonetti MS. Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J Dent Res 2005 Mar;84(3): 269-273.
  7. D'Aiuto F, Parkar M Tonetti MS. Periodontal therapy: a novel acute inflammatory model. Inflamm Res 2005 Oct;54(10): 412-414.
  8. D'Aiuto F, Parkar M, Nibali L, Suvan J, Lessem J Tonetti MS. Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. Am Heart J 2006 May;151(5):977-984.
  9. Kinane DF, Riggio MP, Walker KF, MacKenzie D. Shearer B. Bacteraemia following periodontal procedures. J Clin Periodontol 2005 Jul;32(7):708-713.
  10. Forner L, Larsen T, Kilian M. Holmstrup P. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol 2006 Jun;33(6):401-407.
  11. Silness J, Loe H. Periodontal disease in pregnancy. III. Response to local treatment. Acta Odontol Scand 1966 Dec; 24(6):747-759.
  12. Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963 Dec;21:533-551.
  13. Muhleman HR, Son S. Gingival sulcus bleeding: a lading symptom in initial gingivitis. Helv Odontol Acta 1971 Oct;15(2): 107-113.
  14. Heimdahl A, Hall G, Hedberg M, Sandberg H, Söder PÖ, Tuner K, Nord CE. Detection and quantitation by lysis filtration of bacteremia after different oral surgical procedures. J Clinl Microbiol 1990 Oct;28(10):2205-2209.
  15. Birkedal-Hansen H. Role of cytokines and inflammatory mediators in tissue destruction. J Periodont Res 1993 Nov;28(6 Pt 2):500-510.
  16. Madianos PN, Bobetsis YA, Kinane DF. Generation of inflammatory stimuli: how bacteria set up inflammatory responses in the gingiva. J Clin Periodontol 2005 Aug;32(Suppl 6): 57-71.
  17. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1990 Feb;340(6): 448-454.
  18. Ide M, Jagdev D, Coward PY, Crook M, Barclay GR Wilson RF. The short-term effects of treatment of chronic periodontitis on circulating levels of endotoxin, C-reactive protein, tumor necrosis factor-alpha, and interleukin-6. J Periodontol 2004 Mar;75(3):420-428.
  19. Singh J, Straznicky I, Avent M, Goss AN. Antibiotic prophylaxis for endocarditis: time to reconsider. Aus Dent J 2005 Dec;50(4 Suppl 2):S60-S68.
  20. Kuriyama T, Karasawa T, Nakagawa K, Saiki Y, Yamamoto E, Nakamura S. Bacteriologic features and antimicrobial susceptibility in isolates from orofacial odontogenic infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000 Nov;90(5):600-608.
  21. Bulut E, Bulut Ş, Etikan I Koseoglu O. The value of routine antibiotic prophylaxis in mandibular third molar surgery: acute-phase protein levels as indicators of infection. J Oral Sci 2001 Jun;43(2):117-122.
  22. Eren KS, Gürgan CA, Bostanci HS. Evaluation of non-surgical periodontal treatment using 2 time intervals. J Periodontol 2002 Sep;73(9):1015-1019.
  23. Mongardini C, van Steenberghe D, Dekeyser C, Quirynen M. One-stage full- versus partial-mouth disinfection in the treatment of chronic adult or generalized early onset periodontitis. I. Long-term clinical observations. J Periodontol 1999 Jun;70(6):632-645.
  24. Black S, Kushner I, Samols D. C-reactive protein. J Biochem 2004 Nov;279(47):48487-48490.
  25. Ridker PM. C-reactive protein. A simple test to help predict risk of heart attack and stroke. Circulation 2003 Oct;108(12): e81-e85.
  26. Kushner I, Rzewnicki D, Samols D. What does minor elevation of C-reactive protein signify? Am J Med 2006 Feb;119(2):166.e17-166.e28.
  27. Salvi GE, Lang NP. Host response modulation in the management of periodontal diseases. J Clin Periodontol 2005;32(Suppl 6):108-129.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.