International Journal of Experimental Dental Science

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VOLUME 7 , ISSUE 2 ( July-December, 2018 ) > List of Articles

Original Article

A Novel Experimental Model for Dental Implant Research

Murude Yazan, Fethi Atil, Zeynep B Gonen, Ismail D Kocyigit, Umut Tekin

Keywords : Experimental, Implant, Model,Animal

Citation Information : Yazan M, Atil F, Gonen ZB, Kocyigit ID, Tekin U. A Novel Experimental Model for Dental Implant Research. Int J Experiment Dent Sci 2018; 7 (2):43-47.

DOI: 10.5005/jp-journals-10029-1174

License: CC BY-NC 4.0

Published Online: 00-12-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: Femur, tibia and iliac bone have been generally preferred at previous experimental implant investigations. Bone mineral density, corticocancellous content of these regions are different from jaws because of having endochondral origins. Immobilization and animal care are difficulties of animal studies used extremities. This study aims to describe a new animal model for experimental dental implant research by using rabbits’ mandibles to eliminate disadvantages of other defined regions. Materials and methods: Custom designed and produced implants were implemented at identified mandibular molar areas of 10 male New Zealand rabbits adequately far away to teeth apices and mental foramen. Four mm lengthened, 2.8 mm diameter SLA Nucleoss (Ýzmir, Turkey) specially produced micro dental implants were placed at identified regions of rabbits’ mandibles. Two implants were used for each rabbit. Osseointegration was observed two months after the operation histomorphology. Results: Osseointegration was not actualized at around three implants and finished successfully without infection at around all other implants. Newly formed osteoid matrix and bone tissue were evaluated in all specimens histologically except three implants. This new mandible implant model presumedly shows more similar results about osseointegration to human experiments because of the intramembranous ossification. This model prevents the movement difficulty and fracture risk caused by extremities usage. Postoperative care gets easier, and surgical approach is more invasive than previously used experimental studies in this model. Conclusion: Specially designed mini implants and more sensitive manipulation are necessities of this new approach. Previously used rabbit models can be compared with this mandible model with regard to implant osseointegration.


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