International Journal of Experimental Dental Science

Register      Login

VOLUME 7 , ISSUE 2 ( July-December, 2018 ) > List of Articles

CASE REPORT

Nonsyndromic Familial Hypodontia in Four Members of a Family: A Case Report

Sapna Singla, SP Singh, Gurvanit Lehl

Keywords : Familial, Hypodontia, Maxillary lateral incisor, Nonsyndromic,Congenital absence

Citation Information : Singla S, Singh S, Lehl G. Nonsyndromic Familial Hypodontia in Four Members of a Family: A Case Report. Int J Experiment Dent Sci 2018; 7 (2):139-142.

DOI: 10.5005/jp-journals-10029-1184

License: CC BY-NC 4.0

Published Online: 00-12-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Hypodontia constitutes one of the most common developmental anomalies in humans. Depending upon its severity, it can have a great impact on the oral health of the affected individuals. The present report concerns four members of a family with hypodontia. Whereas three members had unilateral missing maxillary lateral incisor only, the fourth member had bilateral missing maxillary lateral incisors and right mandibular second premolar. Their general examination did not suggest any syndrome present. On the basis of familial incidence and the absence of any clinical features associated with any syndrome, the final diagnosis of nonsyndromic familial hypodontia was made.


PDF Share
  1. Adeboye SO, Cole BO, Hobson RS, et al. Severe hypodontia in a set of triplets. Br Dent J 2006; 201(2):93-96.
  2. Neville BW, Damm DD, Allen CM, et al. Oral and maxillofacial pathology. Philadelphia: WB Saunders; 1995. p. 60-61.
  3. Thesleff I. Genetic basis of tooth development and dental defects. Acta Odontol Scand 2000;58(5):191-194.
  4. Graber LW. Congenital absence of teeth: a review with emphasis on inheritance patterns. J Am Dent Assoc 1978; 96(2):266-75.
  5. Vahid-Dastjerdi E, Borzabadi-Farahani A, Mahdian M, Amini N. Non-syndromic hypodontia in an Iranian orthodontic population. J Oral Sci 2010;52(3):455-61.
  6. Cobourne MT. Familial human Hypodontia-is it all genes? British Dental Journal 2007;203:203-208.
  7. Tal H. Familial hypodontia in the permanent dentition: a case report. Journal of Dentistry 1981;9(3): 260-264.
  8. Cakur B, Dagistan S, Miloglu Ö, et al. Nonsyndromic Oligodontia in Permanent Dentition: Three Siblings. Internet J of Dent Sci. 2005;3(2).
  9. Gadda RB, Pai KM, Sholapurkar AA. Non-syndromic Oligodontia in Permanent Dentition of Monozygotic Twins: Report of a Rare Case. J Contemp Dent Pract [Internet]. 2010;11(2):71-77.
  10. Pandey P, Ansari AA, Choudhary K, et al. Familial aggregation of maxillary lateral incisor agenesis (MLIA). BMJ Case Rep 2013.
  11. Vinuth DP, Agarwal P, Dube G, et al. Nonsyndromic Familial Oligodontia with Multiple Dens Invaginatus: A Case Report of an Unusual Case. Case Reports in Dentistry; 2013.
  12. Paranjpe A, Sawant P, Kshar A, et al. Rare Case Reports of Non-syndromic Hypodontia– Genes at Work. Oral Surgery, Oral Medicine, Oral Radiology 2014;2(2):14-16.
  13. Tangade SP, Ravishankar TL, Batra M, Shah AF. Familial Hypodontia: A Case Series. Kathmandu Univ Med J 2015;50(2):167-169.
  14. Rosales MLN, Patel PI. Genes Underlying Familial Hypodontia: A Review and Discussion of the Role of Dental Hygienists in Future Research. Journal of Dental Hygiene 2005;79(3): 1-9.
  15. Grahnen H. Hypodontia in the permanent dentition: a clinical and genetic investigation. Odont Rev 1956;7(Suppl 3):1-100.
  16. Vastardis H. The genetics of human tooth agenesis: new discoveries for understanding dental anomalies. Am J Orthod Dentofacial Orthop 2000;117(6):650-656.
  17. Bailit HL. Dental variation among populations: an anthropologic view. Dent Clin North Am 1975;19:125-139.
  18. Vastardis H, Karimbux N, Guthua SW, et al. A human MSX1 homeodomain missense mutation causes selective tooth agenesis. Nat Genet 1996;13(4):417-421.
  19. Lammi L, Halonen K, Pirinen S, et al. A missense mutation in PAX9 in a family with distinct phenotype of oligodontia. Eur J Hum Genet 2003;11(11):866-871.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.