International Journal of Experimental Dental Science

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VOLUME 8 , ISSUE 2 ( July-December, 2019 ) > List of Articles


Local and Systemic Effects of Fluoride in Alginate Impression Materials: A Review

Faiez N Hattab

Keywords : Alginate, Bioavailability, Biological fluids, Caries inhibition, Enamel, Fluoride release

Citation Information : Hattab FN. Local and Systemic Effects of Fluoride in Alginate Impression Materials: A Review. Int J Experiment Dent Sci 2019; 8 (2):51-57.

DOI: 10.5005/jp-journals-10029-1192

License: CC BY-NC 4.0

Published Online: 23-07-2020

Copyright Statement:  Copyright © 2019; The Author(s).


Aim: To review local and systemic effects of fluoride (F) in alginate impression materials. Background: Alginate is the most frequently used impression material in dental practices. The alginate powder contains F compounds as an integral ingredient. Materials and methods: Reviewed articles are categorized into three main categories: laboratory studies including F release, enamel solubility, and enamel F uptake. Animal experiment assessed the anticaries effect of topically applied F and release of F from subcutaneously implanted alginate. Human studies involved F distribution from alginate impressions to saliva and circulatory system as well as alginate ingestion and inhalation of the alginate dust. Review results: In vitro and in vivo findings indicated that alginate continuously released F in aqueous solution. Topical application of alginate resulted in significant enamel F uptake and reduced enamel solubility. Animal experiment showed that topically applied alginate resulted in a significant inhibition of caries. Subcutaneously implanted alginate continuously released F. Human studies revealed that F in alginate impression are readily taken in and distributed to saliva and blood. Deliberately ingested alginate raised plasma F to considerable level. The F inhaled from emitted alginate dust did not elevate the plasma F level. Conclusion: The outcome of this overview indicates that alginate impression materials are rich source of F delivery to dental tissues, oral fluids, and systemic circulation. Clinical significance: The beneficial local effects of F in alginate impression materials have been discussed. On the other hand, alginate impressions elevate the plasma F levels if the pooled saliva is swallowed or part of the material is accidentally ingested. Dental professionals require to familiarize with these aspects.

  1. Jain D, Bar-Shalom D. Alginate drug delivery systems: application in context of pharmaceutical and biomedical research. Drug Dev Ind Pharm 2014;40(12):1576–1584. DOI: 10.3109/03639045.2014.917657.
  2. Hattab FN, Duwayri ZN. Management of patient's gag reflex in making an irreversible hydrocolloid impression. J Prosthet Dent 1999;81(3):369. DOI: 10.1016/S0022-3913(99)70282-9.
  3. Hesselgren SG. Method of applying preventive and therapeutic agents. US3964164 A 1976.
  4. Craig RG. Review of dental impression materials. Adv Dent Res 1988;2(1):51–64. DOI: 10.1177/08959374880020012001.
  5. Anusavice KJ, Kenneth J. Phillips’ Science of Dental Materials, 11th ed. Elsevier; 2003. pp. 210–230.
  6. Hattab F, Frostell G. The release of fluoride from alginate impression materials. Community Dent Oral Epidemiol 1978;6(5):273–274. DOI: 10.1111/j.1600-0528.1978.tb01164.x.
  7. Hattab F, Frostell G. The release of fluoride from two products of alginate impression materials. Acta Odontol Scand 1980;38(6):385–395. DOI: 10.3109/00016358009033609.
  8. Hattab F. Absorption of fluoride following inhalation and ingestion of alginate impression materials. Pharmacol Ther Dent 1981;6(3–4):79–86.
  9. Whitford GM, Ekstrand J, Callan RS, et al. Subcutaneously implanted alginate as a continuous-release source of fluoride. J Dent Res 1980;59(2):186–191. DOI: 10.1177/00220345800590021901.
  10. Braga AS, Catirse ABC, Vaz LG, et al. Quantitative analysis of fluorides in alginates for dental use. J Basic Appl Pharm Sci 2005;26(3):181–188.
  11. Lee YK, Lim BS, Kim CW. Effect of fluoride addition on the properties of dental alginate impression materials. J Mater Sci Mater Med 2004;15(3):219–224. DOI: 10.1023/B:JMSM.0000015481.04144.57.
  12. Whitford GM, Ekstrand J. Systemic absorption of fluoride from alginate impression material in humans. J Dent Res 1980;59(5):782–785. DOI: 10.1177/00220345800590050601.
  13. Hattab F. Effect of fluoride-containing alginates and gels on the acid resistance of demineralized human enamel. Acta Odontol Scand 1984;42(3):175–181. DOI: 10.3109/00016358408993869.
  14. Hattab FN, Wei SHY. Chemical changes and surface morphology of acid-etching of human enamel treated with topical fluoride agents in vitro. Caries Res 1987;21:282–293. DOI: 10.1159/000261057.
  15. LeCompte EJ, Whitford GM. The biologic availability of fluoride from alginate impressions and APF gel applications in children. J Dent Res 1981;60(4):776–780. DOI: 10.1177/00220345810600040201.
  16. Hattab F. Effect of topical application of alginate containing fluoride or fluoride and chlorhexidine on dental caries in rats. Caries Res 1984;18(4):367–374. DOI: 10.1159/000260789.
  17. Regolati B, Schmid R, Mühlemann HR. Combination of chlorhexidine and fluoride in caries prevention. An animal experiment. Helv odont Acta 1974;18:12–16.
  18. Hefti A. Effect of topical fluoride gel application on caries incidence in rats. Caries Res 1982;16(1):77–79. DOI: 10.1159/000260580.
  19. Hattab F, Lindén L-Å. Diffusion of fluoride from alginate compared with other topical fluoride agents. Scand J Dent Res 1985;93(3):269–275. DOI: 10.1111/j.1600-0722.1985.tb01956.x.
  20. Margolis HC, Moreno EC. Physicochemical perspectives on the cariostatic mechanisms of systemic and topical fluorides. J Dent Res 1990;69:606–613. DOI: 10.1177/00220345900690S119.
  21. Wiegand A, Buchalla W, Attin T. Review on fluoride-releasing restorative materials—fluoride release and uptake characteristics, antibacterial activity and influence on caries formation. Dent Mater 2007;23(3):343–362. DOI: 10.1016/
  22. Seppä L. Effects of a sodium fluoride solution and a varnish with different fluoride concentrations on enamel remineralization in vitro. Scand J Dent Res 1988;96(4):304–309. DOI: 10.1111/j.1600-0722.1988.tb01560.x.
  23. Mellberg JR. Evaluation of topical fluoride preparations. J Dent Res 1990;69:771–779. DOI: 10.1177/00220345900690S149.
  24. Featherstone JDB. Prevention and reversal of dental caries: role of low level of fluoride. Community Dent Oral Epidemiol 1999;27(1):31–40. DOI: 10.1111/j.1600-0528.1999.tb01989.x.
  25. Lynch RJM, Navada R, Walia R. Low-levels of fluoride in plaque and saliva and their effects on the demineralisation and remineralisation of enamel; role of fluoride toothpastes. Int Dent J 2004;54(5 Suppl 1):304–309. DOI: 10.1111/j.1875-595X.2004.tb00003.x.
  26. Hattab FN, Green RM, Pang KM, et al. Effect of fluoride-containing chewing gum on remineralization of carious lesions and on fluoride uptake in man. Clin Prev Dent 1989;11(6):6–11.
  27. Zero DT, Fu J, Espeland MA, et al. Comparison of fluoride concentrations in unstimulated whole saliva following the use of a fluoride dentifrice and a fluoride rinse. J Dent Res 1988;67(10):1257–1262. DOI: 10.1177/00220345880670100201.
  28. Oliveby A, Ekstrand J, Lagerlof F. Effect of salivary flow rate on salivary fluoride clearance after use of a fluoride-containing chewing gum. Caries Res 1987;21(5):393–401. DOI: 10.1159/000261045.
  29. Hattab FN, Baghdady VS, Ghose LJ. Effect of sodium fluoride mouthrinsing on enamel solubility and levels of fluoride in enamel and in whole saliva. J Int Assoc Dent Child 1987;18(2):29–35.
  30. Ekstrand J, Koch G, Lindgren LE, et al. Pharmacokinetics of fluoride gels in children and adults. Caries Res 1981;15(3):213–220. DOI: 10.1159/000260517.
  31. Angmar-Månsson B, Ericsson Y, Ekberg O. Plasma fluoride and enamel fluorosis. Calcif Tissue Res 1976;22(1):77–84. DOI: 10.1007/BF02010348.
  32. DENTSPLY/Caulk. Safety Data Sheet/alginate. From: [].
  33. Henry Schein. Safety Data Sheet /alginate. From: [].
  34. Dental Alginate/Barnes Products P/L. Safety Data Sheet. From:].
  35. Ormco Corporation. Safety Data Sheet/alginate. From: [].
  36. Wei SHY, Hattab FN. Water fluoridation, systemic fluorides, and fluoride metabolism. In: Wei SHY, ed. Pediatric Dentistry: Total Patient Care. Philadelphia: Lea & Febiger; 1988.
  37. de Freitas JF. Potential toxicants in alginate powders. Aust Dent J 1980;25(4):224–228. DOI: 10.1111/j.1834-7819.1980.tb03870.x.
  38. Brune D, Beltesbrekke H. Levels of airborne particles resulting from handling alginate impression material. Scand J Dent Res 1978;86(3):206–210. DOI: 10.1111/j.1600-0722.1978.tb01933.x.
  39. Ehrnebo M, Ekstrand J. Occupational fluoride exposure and plasma fluoride levels in man. Int Arch Occup Environ Health 1986;58(3):179–190. DOI: 10.1007/BF00432099.
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