International Journal of Experimental Dental Science

Register      Login

VOLUME 9 , ISSUE 2 ( July-December, 2020 ) > List of Articles

RESEARCH ARTICLE

Histomorphometric Study of Neuroglial Elements of Trigeminal Ganglion in Young Adult and Aged Animals Following Tooth Extraction

Shahriar Ahmadpour, Arman Behrad, Khadijeh Foghi, Luis Rafael Moscte-Salazar

Keywords : Neuroglial, Neuropathy, Tooth extraction, Trigeminal ganglion

Citation Information : Ahmadpour S, Behrad A, Foghi K, Moscte-Salazar LR. Histomorphometric Study of Neuroglial Elements of Trigeminal Ganglion in Young Adult and Aged Animals Following Tooth Extraction. Int J Experiment Dent Sci 2020; 9 (2):43-46.

DOI: 10.5005/jp-journals-10029-1206

License: CC BY-NC 4.0

Published Online: 01-12-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Trigeminal ganglion (TG) is the main sensory ganglion of the orofacial regions associated with neuropathic pain. TG comprises pseudo-unipolar neurons with different morphologies and two types of glial cells, including Schwann cells and satellite glial cells (SGC). We designed this study to examine the effects of tooth extraction (as a cause of neuropathic pain) on the morphological and population change in SGC and neurons of the TG in aged and young adult animals. The results of our current study revealed that tooth extraction is not associated with quantitative changes in the number of SGC and leads to morphological changes in heterogeneous SGC of the ipsilateral side. The hypertrophic SGC was the most striking microscopic feature of the study. Additionally, quantitative changes in the pattern distribution and morphometry of neurons and the dynamic nature of the TG after tooth extraction particularly in aging was the other finding of our study.


PDF Share
  1. Lagares A, Avendaño C. Lateral asymmetries in the trigeminal ganglion of the male rat. Brain Res 2000;865(2):202–210.
  2. Pk S, Al Dajah SRSB. Morphological study of nociceptive neurons in the trigeminal ganglion. Int J Health Rehab Sci 2017;5(1):1–10.
  3. Gunjigake KK, Goto T, Nakao K, et al. Activation of satellite glial cells in rat trigeminal ganglion after upper molar extraction. Acta Histochem Cytochem 2009;42(5):143–149.
  4. Costa FAL, Neto FLM. Satellite glial cells in sensory ganglia: its role in pain. Rev Bras Anestesiol 2015;65(1):73–81.
  5. Ohara PT, Vit JP, Bhargava A, et al. Gliopathic pain: when satellite glial cells go bad. Neuroscientist 2009;15(5):450–463.
  6. Tinastepe N, Oral K. Neuropathic pain after dental treatment. Agri 2013;25(1):1–6.
  7. Kubo K-y, Murabayashi C, Kotachi M, et al. Tooth loss early in life suppresses neurogenesis and synaptophysin expression in the hippocampus and impairs learning in mice. Arch Oral Biol 2017;74:21–27.
  8. Dioguardi M, Di Gioia G, Caloro GA, et al. The association between tooth loss and Alzheimer's disease: a systematic review with meta-analysis of case control studies. Dent J (Basel) 2019;7(2):49.
  9. Palmer AL, Ousman SS. Astrocytes and aging. Front Aging Neurosci 2018;10:337.
  10. Ahmadpour S, Foghi K, Behrad A. Chronic exposure to ketamine induces neuronal lose and glial reaction in CA4 region of hippocampus. J Morphol Sci 2016;33(2):103–107.
  11. Bancroft J, Stevens A, Tumer D. Theory and practice of histological techniques. 3rd ed., Edinburgh: Churchil Livinsgstone; 1990. pp. 360–361.
  12. Verkhratsky A, Nedergaard M. Physiology of astroglia. Physiol Rev 2018;98(1):239–389.
  13. Gu Y, Chen Y, Zhang X, et al. Neuronal soma–satellite glial cell interactions in sensory ganglia and the participation of purinergic receptors. Neuron Glia Biol 2010;6(1):53–62.
  14. Berge TI. Incidence of chronic neuropathic pain subsequent to surgical removal of impacted third molars. Acta Odontol Scand 2002;60(2):108–112.
  15. Iinuma M, Kondo H, Kurahashi M, et al. Relationship between the early toothless condition and hippocampal functional morphology. Anat Physiol 2014;4(3):8–13.
  16. Onozuka M, Watanabe K, Fujita M, et al. Evidence for involvement of glucocorticoid response in the hippocampal changes in aged molarless SAMP8 mice. Behav Brain Res 2002;131(1-2):125–129.
  17. Hatashita S, Sekiguchi M, Kobayashi H, et al. Contralateral neuropathic pain and neuropathology in dorsal root ganglion and spinal cord following hemilateral nerve injury in rats. Spine 2008;33(12):1344–1351.
  18. Bear MF, Connors BW, Paradiso MA. Neuroscience. Filadelfia: Lippincott Williams and Wilkins; 2007.
  19. Lynds R, Lyu C, Lyu GW, et al. Neuronal plasticity of trigeminal ganglia in mice following nerve injury. J Pain Res 2017;10:349.
  20. Jacquin MF, Rhoades RW. Development and plasticity in hamster trigeminal primary afferent projections. Dev Brain Res 1987;31(2):161–175.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.