International Journal of Experimental Dental Science

Register      Login

VOLUME 4 , ISSUE 1 ( January-June, 2015 ) > List of Articles

RESEARCH ARTICLE

Fibrin Sealant: A Review of Its Applications in Periodontal Surgery

Shaju Jacob Pulikkotil, Sonia Nath

Citation Information : Pulikkotil S J, Nath S. Fibrin Sealant: A Review of Its Applications in Periodontal Surgery. Int J Experiment Dent Sci 2015; 4 (1):40-46.

DOI: 10.5005/jp-journals-10029-1093

License: CC BY-SA 3.0

Published Online: 01-12-2015

Copyright Statement:  Copyright © 2015; The Author(s).


Abstract

Aim

Fibrin sealant is a biological tissue adhesive mimicking the final stage of coagulation. It has a wide variety of application in the field of periodontics. The aim of this article was to review current applications and identify potential use of fibrin sealant in periodontal surgical procedures on an evidence-based conclusion.

Materials and methods

An online search was performed in PubMed, Google Scholar and Cochrane Library databases using keywords fibrin sealant, fibrin glue, fibrin, regeneration, wound healing, tissue adhesive, gingival recession/therapy, surgical therapy, periodontal, and periodontitis in a mutually inclusive manner. The studies were evaluated by two independent reviewers for inclusion in this literature review.

Results

Out of 196 research papers identified, 59 articles were selected by the authors for this literature review, giving preference to clinical trials related to periodontal application.

Conclusion

Use of fibrin sealant is a simple, safe, costeffective, and rapid way to fix flaps and grafts avoiding any postoperative bleeding. Fibrin sealant has the property for regeneration when used in conjunction with a barrier membrane for formation of new connective tissue attachment. It is effective in microsurgical procedures and closing flaps around implant site. They initiate early wound healing through collagen synthesis and fibroblast proliferation. Fibrin sealant may be an alternate biomaterial for periodontal surgery which may stimulate periodontal wound healing and regeneration.

How to cite this article

Jacob S, Nath S. Fibrin Sealant: A Review of Its Applications in Periodontal Surgery. Int J Experiment Dent Sci 2015;4(1):40-46.


PDF Share
  1. Etiology and pathogenesis of periodontal diseases. Dent Clin North Am 2005;49(3):491-516.
  2. Microbiology in diagnosis and treatment planning in periodontics. Int J Dent Hyg 2003;1(3):131-137.
  3. Inflammation and bone loss in periodontal disease. J Periodontol 2008;79(8):1569-1576.
  4. Periodontal regeneration. Aust Dent J 2009;54(1):S118-128.
  5. Prevention of periodontal diseases. Dent Clin North Am 2005;49(3):573-594.
  6. Future approaches in periodontal regeneration: gene therapy, stem cells, and RNA interference. Dent Clin North Am 2010;54(1):141-155.
  7. Regeneration of periodontal tissue: bone replacement grafts. Dent Clin North Am 2010;54(1):55-71.
  8. Periodontal regeneration: a challenge for the tissue engineer. Proc Inst Mech Eng H 2010;224(12):1345-1358.
  9. On the use of a biologic sealing system (Tissucol) in periodontal surgery. Int J Periodont Restorat Dent 1983;3(4):48-60.
  10. On the use of a biologic sealing system (Tissucol) in periodontal therapy—II: histologic evaluation. Int J Periodont Restorat Dent 1985;5(3):32-41.
  11. Fibrin as a haemostatic in cerebral surgery. Surg Gun Obst 1915;21:452-453.
  12. Fibrin suture of peripheral nerves. Lancet 1940;2:126.
  13. Preliminary observations on the use of a biologic sealing system (Tissucol) in periodontal surgery. J Periodontol 1982;53(12):731-735.
  14. Human fibrin glue versus sutures in periodontal flap surgery. J Periodont 1987;58(6):426-431.
  15. The role of sutures and fibrin sealant in wound healing. Surg Clin North Am 1997;77(3):651-669.
  16. Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95(5): 521-528.
  17. Guided tissue regeneration procedure using a fibrinfibronectin system in surgically induced recession in dogs. Int J Periodont Restorat Dent 1991;11(2):150-163.
  18. In vivo alveolar bone regeneration by bone marrow stem cells/fibrin glue composition. Arch Oral Biol 2012;57(3):238-244.
  19. Fibrin glue mixed with platelet-rich fibrin as a scaffold seeded with dental bud cells for tooth regeneration. J Tissue Eng Regen Med 2012;6(10):777-785.
  20. Current applications of platelet gels in facial plastic surgery. Facial Plast Surg 2002;18(1):27-33.
  21. Use of thrombin and fibrinogen in skin grafting. JAMA 1944;124:976-978.
  22. Experimental investigations of the effect of the fibrin adhesive on the Kiel heterologous bone graft. Arch Orthop Trauma Surg 1980; 96(3):177-185.
  23. Fibrin glue in ophthalmology. Ind J Ophthalmol 2009;57(5):371-379.
  24. Organic glues or fibrin glues from pooled plasma: efficacy, safety and potential as scaffold delivery systems. J Pharm Pharm Sci 2012;15(1):124-140.
  25. Fibrin sealant: clinical use and the development of the University of Virginia Tissue Adhesive Center. Ann Clin Lab Sci 2001;31(1):108-118.
  26. Theoretical and clinical considerations for autologous blood preparations: platelet-rich plasma, fibrin sealants, and plasma-rich growth factors. Clin Adv Periodontics 2011;1(2):142-153.
  27. Thromboelastograph assay for measuring the mechanical strength of fibrin sealant clots. Clinical and Applied Thrombosis/Hemostasis 2000;6(4):226-233.
  28. Mechanical properties of surgical glues used in aortic root replacement. Ann Thorac Surg 2009;87(4):1154-1160.
  29. Use of fibrin glue in periodontal flap surgery. J Ind Soc Periodont 2008;12(1):21-25.
  30. Development of a model for measurement of adhesion strength of fibrin sealant to human tissue. Eur Surg Res 1999;31(6):491-496.
  31. Regeneration of the connective tissue attachment on surgically exposed roots using a fibrin-fibronectin adhesive system: an experimental on the baboon (Papio ursinus). J Periodontal Res 1987;22(4):320-326.
  32. Fibrin sealant in orthopedic surgery. Clin Orthop Relat Res 1988;227:269-285.
  33. Fibrin sealant in vascular surgery: a review. J Long Term Eff Med Implants 1998;8(2):117-132.
  34. The addition of antibiotics to fibrin glue. South Med J 1997;90(7):681-684.
  35. A comparative study on the efficacy of a commercial fibrin adhesive (Tisseel) vis-à-vis silk suture on wound closure following periodontal surgical procedures. J Ind Soc Periodontol 2010;14(4):231-235.
  36. Effect of Tisseel on healing after periodontal flap surgery. J Clin Periodontol 1992;19(7): 449-454.
  37. Effect of tissucol on connective tissue matrix during wound healing: an immunohistochemical study in rat skin. J Biomed Mater Res 1998;39(3):462-468.
  38. Fibrin sealant as an alternative for sutures in periodontal surgery. J Coll Physicians Surg Pak 2013;23(2):164-165.
  39. A review of bioceramics and fibrin sealant. Eur Cell Mater 2004;8:1-10.
  40. No detrimental effect of fibrin glue on the regeneration of intrabony defects: a controlled clinical trial. J Clin Periodontol 1995;22(9):697-702.
  41. Periodontal tissue regeneration using fibrin tissue adhesive material in vitro and in vivo. Periodontal Clin Investig 1996;18(1):26-38.
  42. Periodontal healing following guided tissue regeneration with citric acid and fibronectin application. J Periodontol 1991;62(1):21-29.
  43. The use of bovine porous bone mineral in combination with enamel matrix proteins or with an autologous fibrinogen/fibronectin system in the treatment of intrabony periodontal defects in humans. J Periodontol 2001;72(9):1157-1163.
  44. Orthodontic movement into bone defects augmented with bovine bone mineral and fibrin sealer: a reentry case report. Int J Periodont Rest Dent 2002;22(2):138-145.
  45. Fibrin linkage: a precursor for new attachment. J Periodontol 1983;54(3):141-147.
  46. Extracellular matrices and polypeptide growth factors as mediators of functions of cells of the periodontium. J Periodontol 1987;58(6):371-380.
  47. Effects of a fibrin-fibronectin sealing system on proliferation and type I collagen synthesis of human PDL fibroblasts in vitro. J Clin Periodontol 1998;25(1):11-14.
  48. Fibrin and fibronectin sealing system in a guided tissue regeneration procedure: a case report. J Periodontol 1988;59(10):679-683.
  49. Fibrin glue application in conjunction with tetracycline root conditioning and coronally positioned flap procedure in the treatment of human gingival recession defects. J Clin Periodontol 1996;23(9):861-867.
  50. Effects of tetracycline HCl conditioning and fibrin-fibronectin system application in the treatment of buccal gingival recession with guided tissue regeneration. J Periodontol 1995;66(5):313-320.
  51. Combined guided tissue regeneration, root conditioning, and fibrinfibronectin system application in the treatment of gingival recession: a 15 case report. J Periodontol 1994;65(8):796-803.
  52. Complete root coverage of denuded root surface using expanded polytetrafluoroethylene membrane in conjunction with tetracycline root conditioning and fibrin-fibronectin glue application: case reports. Quintessence Int 1993;24(12):847-852.
  53. Combined use of root conditioning, fibrin-fibronectin system and a collagen membrane to treat a localized gingival recession: a 10 case report. J Marmara Univ Dent Fac 1997;2(4):588-598.
  54. Fibrin sealants in implant and periodontal treatment: case presentations. Compend Contin Educ Dent 2005;26(8):539-544.
  55. Platelet-enriched fibrin glue and platelet-rich plasma in the repair of bone defects adjacent to titanium dental implants. Int J Oral Maxillofac Implants 2007;22(3):417-422.
  56. Long-term evaluation of osseointegrated implants in regenerated and non regenerated bone. Int J Periodont Restor Dent 2000;20(4):390-397.
  57. Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation. Blood 2000;96(12):3772-3778.
  58. Controlled release of bioactive transforming growth factor beta-1 from fibrin gels in vitro. Tissue Eng Part C Methods 2008;14(2):119-128.
  59. Fibrin-based biomaterials to deliver human growth factors. Thromb Haemost 2003;89(3):573-582.
  60. Biological in vitro effects of fibrin glue: fibroblast proliferation, expression and binding of growth factors. Scand J Gastroenterol 2004;39(10): 927-932.
  61. The effect of basic fibroblast growth factor on delayed-replanted monkey teeth. J Periodontol 2004;75(12):1570-1578.
  62. Fibrin glue as a vehicle for mesenchymal stem cell delivery in bone regeneration. J Chin Med Assoc 2008;71(2): 59-61.
  63. Experimental use of an elastomeric surgical sealant for arterial hemostasis and its long-term tissue response. Interact Cardiovasc Thorac Surg 2010;10(2):258-261.
  64. Comparison of the effectiveness of autologous fibrin glue and macroporous biphasic calcium phosphate as carriers in the osteogenesis process with or without mesenchymal stem cells. J Chin Med Assoc 2008;71(2):66-73.
  65. Treatment of experimental osteomyelitis with a fibrin sealant antibiotic implant. Clin Orthop Relat Res 2002; 403:58-72.
  66. Ozone therapy in dentistry: a strategic review. J Nat Sc Biol Med 2011;2(2):151-153.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.